Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM469435
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
0.600±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469435
Synonyms:
US10807988, Example SC_3076 | cis-1-(Cyclobutyl-methyl)-8-dimethylamino-3-(2-methoxy-pyrimidin-5-yl)-8- phenyl-1,3-diazaspiro[4.5]decan-2-one
Type:
Small organic molecule
Emp. Form.:
C26H35N5O2
Mol. Mass.:
449.5884
SMILES:
COc1ncc(cn1)N1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O |r,wU:10.27,13.17,(-7.19,-2.27,;-5.7,-1.87,;-4.62,-2.96,;-3.13,-2.56,;-2.04,-3.65,;-2.44,-5.14,;-3.93,-5.54,;-5.01,-4.45,;-1.35,-6.23,;.12,-5.75,;1.02,-7,;1.79,-8.33,;3.33,-8.33,;4.1,-7,;3.33,-5.66,;1.79,-5.66,;4.87,-5.66,;4.1,-4.33,;6.41,-5.66,;4.87,-8.33,;4.1,-9.67,;4.87,-11,;6.41,-11,;7.18,-9.67,;6.41,-8.33,;.12,-8.24,;.59,-9.71,;-.44,-10.85,;-1.98,-10.85,;-1.98,-12.39,;-.44,-12.39,;-1.35,-7.77,;-2.59,-8.67,)|
Structure:
Search PDB for entries with ligand similarity: