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Target
Nociceptin receptor
Ligand
BDBM469438
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.60±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469438
Synonyms:
US10807988, Example SC_3079 | cis-1-(Cyclobutyl-methyl)-8-dimethylamino-3-(5-fluoro-pyrimidin-2-yl)-8-phenyl- 1,3-diazaspiro[4.5]decan-2-one
Type:
Small organic molecule
Emp. Form.:
C25H32FN5O
Mol. Mass.:
437.5529
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2CCC2)c2ncc(F)cn2)CC1)c1ccccc1 |r,wU:6.11,3.2,(3.44,10.6,;4.21,9.26,;5.75,9.26,;3.44,7.93,;2.67,6.6,;1.13,6.6,;.36,7.93,;-.54,9.17,;-2.01,8.7,;-2.01,7.16,;-3.25,6.25,;-.54,6.68,;-.07,5.22,;-1.1,4.07,;-2.64,4.07,;-2.64,2.53,;-1.1,2.53,;-3.1,9.79,;-2.7,11.28,;-3.79,12.36,;-5.28,11.97,;-6.36,13.05,;-5.67,10.48,;-4.59,9.39,;1.13,9.26,;2.67,9.26,;4.21,6.6,;3.44,5.26,;4.21,3.93,;5.75,3.93,;6.52,5.26,;5.75,6.6,)|
Structure:
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