Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM469444
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.60±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469444
Synonyms:
US10807988, Example SC_3085 | cis-1-(Cyclobutyl-methyl)-8-dimethylamino-8-phenyl-3-[6-(trifluoromethyl)- pyridin-3-yl]-1,3-diazaspiro[4.5]decan-2-one
Type:
Small organic molecule
Emp. Form.:
C27H33F3N4O
Mol. Mass.:
486.5723
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2CCC2)c2ccc(nc2)C(F)(F)F)CC1)c1ccccc1 |r,wU:6.11,3.2,(4.18,-18.61,;4.95,-19.94,;6.49,-19.94,;4.18,-21.27,;3.41,-22.61,;1.87,-22.61,;1.1,-21.27,;.19,-20.03,;-1.27,-20.5,;-1.27,-22.04,;-2.52,-22.95,;.19,-22.52,;.67,-23.99,;-.36,-25.13,;-1.9,-25.13,;-1.9,-26.67,;-.36,-26.67,;-2.36,-19.42,;-3.85,-19.81,;-4.94,-18.73,;-4.54,-17.24,;-3.05,-16.84,;-1.96,-17.93,;-5.63,-16.15,;-7.11,-16.55,;-5.23,-14.66,;-6.71,-15.06,;1.87,-19.94,;3.41,-19.94,;4.95,-22.61,;4.18,-23.94,;4.95,-25.28,;6.49,-25.28,;7.26,-23.94,;6.49,-22.61,)|
Structure:
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