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Target
Nociceptin receptor
Ligand
BDBM469458
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.000±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469458
Synonyms:
US10807988, Example SC_3100 | cis-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-methyl]-8-phenyl-3-(2-piperazin- 1-yl-pyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one hydrochloride
Type:
Small organic molecule
Emp. Form.:
C29H41N7O2
Mol. Mass.:
519.6815
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2(O)CCC2)c2cnc(nc2)N2CCNCC2)CC1)c1ccccc1 |r,wU:6.11,3.2,(5.13,-7.04,;5.9,-8.37,;7.44,-8.37,;5.13,-9.7,;4.36,-11.04,;2.82,-11.04,;2.05,-9.7,;1.15,-8.46,;-.32,-8.93,;-.32,-10.47,;-1.57,-11.38,;1.15,-10.95,;1.62,-12.41,;.59,-13.56,;2.08,-13.96,;-.95,-13.56,;-.95,-15.1,;.59,-15.1,;-1.5,-7.94,;-2.94,-8.46,;-4.12,-7.47,;-3.85,-5.95,;-2.4,-5.43,;-1.22,-6.42,;-5.03,-4.96,;-4.75,-3.44,;-5.93,-2.45,;-7.38,-2.97,;-7.65,-4.49,;-6.47,-5.48,;2.82,-8.37,;4.36,-8.37,;5.9,-11.04,;5.13,-12.37,;5.9,-13.7,;7.44,-13.7,;8.21,-12.37,;7.44,-11.04,)|
Structure:
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