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Target
Nociceptin receptor
Ligand
BDBM469459
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.000±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469459
Synonyms:
US10807988, Example SC_3101 | cis-1-[(1-Hydroxy-cyclobutyl1)-methyl]-8-methylamino-3-[2-(4-methyl-piperazin- 1-yl)-pyrimidin-5-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one
Type:
Small organic molecule
Emp. Form.:
C29H41N7O2
Mol. Mass.:
519.6815
SMILES:
CN[C@]1(CC[C@]2(CN(C(=O)N2CC2(O)CCC2)c2cnc(nc2)N2CCN(C)CC2)CC1)c1ccccc1 |r,wU:5.10,2.1,(4.75,23.16,;5.52,21.83,;4.75,20.49,;3.98,19.16,;2.44,19.16,;1.67,20.49,;.76,21.74,;-.7,21.26,;-.7,19.72,;-1.95,18.82,;.76,19.25,;1.24,17.78,;.21,16.64,;1.7,16.24,;-1.33,16.64,;-1.33,15.1,;.21,15.1,;-1.88,22.26,;-3.33,21.73,;-4.5,22.73,;-4.23,24.24,;-2.78,24.76,;-1.61,23.77,;-5.41,25.24,;-5.14,26.75,;-6.31,27.74,;-7.76,27.22,;-8.94,28.22,;-8.03,25.71,;-6.86,24.71,;2.44,21.83,;3.98,21.83,;5.52,19.16,;4.75,17.82,;5.52,16.49,;7.06,16.49,;7.83,17.82,;7.06,19.16,)|
Structure:
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