Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM469469
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
2.00±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469469
Synonyms:
US10807988, Example SC_3107 | cis-1-(Cyclopropyl-methyl)-8-dimethylamino-3-(2-fluoro-4-methylsulfonyl- phenyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one
Type:
Small organic molecule
Emp. Form.:
C27H34FN3O3S
Mol. Mass.:
499.641
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2CC2)c2ccc(cc2F)S(C)(=O)=O)CC1)c1ccccc1 |r,wU:6.11,3.2,(4.05,-5.59,;4.82,-6.92,;6.36,-6.92,;4.05,-8.25,;3.28,-9.59,;1.74,-9.59,;.97,-8.25,;.07,-7.01,;-1.4,-7.48,;-1.4,-9.02,;-2.64,-9.93,;.07,-9.5,;.54,-10.96,;-.49,-12.11,;-1.95,-12.58,;-.81,-13.61,;-2.73,-6.71,;-4.06,-7.48,;-5.4,-6.71,;-5.4,-5.17,;-4.06,-4.4,;-2.73,-5.17,;-1.4,-4.4,;-6.73,-4.4,;-6.73,-2.86,;-8.27,-4.4,;-7.5,-5.74,;1.74,-6.92,;3.28,-6.92,;4.82,-9.59,;4.05,-10.92,;4.82,-12.25,;6.36,-12.25,;7.13,-10.92,;6.36,-9.59,)|
Structure:
Search PDB for entries with ligand similarity: