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Target
Nociceptin receptor
Ligand
BDBM469673
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
2.00±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469673
Synonyms:
US10807988, Example SC_3308 | cis-8-Dimethylamino-3-[6-morpholin-4-yl-5-(trifluoromethyl)-pyridin-3-yl]-8- phenyl-1,3-diazaspiro[4.5]decan-2-one
Type:
Small organic molecule
Emp. Form.:
C26H32F3N5O2
Mol. Mass.:
503.5598
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2)c2cnc(N3CCOCC3)c(c2)C(F)(F)F)CC1)c1ccccc1 |r,wU:6.11,3.2,(-3.65,21.65,;-5.19,21.65,;-5.96,22.99,;-5.96,20.32,;-6.73,18.99,;-8.27,18.99,;-9.04,20.32,;-9.94,21.57,;-11.41,21.09,;-11.41,19.55,;-12.74,18.78,;-9.94,19.07,;-12.74,21.86,;-14.07,21.09,;-15.41,21.86,;-15.41,23.4,;-16.74,24.17,;-16.74,25.71,;-18.07,26.48,;-19.41,25.71,;-19.41,24.17,;-18.07,23.4,;-14.07,24.17,;-12.74,23.4,;-14.07,25.71,;-12.74,26.48,;-15.41,26.48,;-14.07,27.25,;-8.27,21.65,;-6.73,21.65,;-5.19,18.99,;-5.96,17.65,;-5.19,16.32,;-3.65,16.32,;-2.88,17.65,;-3.65,18.99,)|
Structure:
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