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Target
Nociceptin receptor
Ligand
BDBM469695
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
2.00±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469695
Synonyms:
US10807988, Example SC_3331 | cis-8-Dimethylamino-3-[2-(2-oxo-1,3-dihydro-indol-4-yl)-pyrimidin-5-yl]-8- thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one
Type:
Small organic molecule
Emp. Form.:
C26H28N6O2S
Mol. Mass.:
488.605
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2)c2cnc(nc2)-c2cccc3NC(=O)Cc23)CC1)c1cccs1 |r,wU:6.11,3.2,(19.44,1.69,;17.96,2.09,;17.56,3.58,;16.87,1,;16.1,-.33,;14.56,-.33,;13.79,1,;12.88,2.25,;11.42,1.77,;11.42,.23,;10.08,-.54,;12.88,-.24,;10.17,2.52,;10.17,4.06,;8.83,4.83,;7.5,4.06,;7.5,2.52,;8.83,1.75,;6.16,4.83,;6.16,6.37,;4.83,7.14,;3.5,6.37,;3.5,4.83,;2.35,3.8,;2.98,2.39,;2.21,1.06,;4.51,2.55,;4.83,4.06,;14.56,2.34,;16.1,2.34,;17.96,-.09,;17.72,-1.61,;19.09,-2.31,;20.18,-1.22,;19.48,.15,)|
Structure:
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