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Target
Nociceptin receptor
Ligand
BDBM469708
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.000±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469708
Synonyms:
US10807988, Example SC_3344 | cis-8-Dimethylamino-3-[2-(1-oxo-2,3-dihydro-isoindol-4-yl)-pyrimidin-5-yl]-8- phenyl-1,3-diazaspiro[4.5]decan-2-one; 2,2,2-trifluoro-acetic acid
Type:
Small organic molecule
Emp. Form.:
C28H30N6O2
Mol. Mass.:
482.5768
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2)c2cnc(nc2)-c2cccc3C(=O)NCc23)CC1)c1ccccc1 |r,wU:6.11,3.2,(-1.54,-1.31,;-3.03,-.91,;-3.43,.58,;-4.12,-2,;-4.89,-3.33,;-6.43,-3.33,;-7.2,-2,;-8.1,-.75,;-9.57,-1.23,;-9.57,-2.77,;-10.9,-3.54,;-8.1,-3.24,;-10.58,-.18,;-10.19,1.31,;-11.27,2.39,;-12.76,2,;-13.16,.51,;-12.07,-.58,;-13.85,3.09,;-13.45,4.57,;-14.54,5.66,;-16.03,5.26,;-16.43,3.78,;-17.8,3.08,;-19.29,3.47,;-17.56,1.56,;-16.04,1.31,;-15.34,2.69,;-6.43,-.66,;-4.89,-.66,;-3.03,-3.09,;-3.43,-4.57,;-2.34,-5.66,;-.85,-5.26,;-.45,-3.78,;-1.54,-2.69,)|
Structure:
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