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Target
Nociceptin receptor
Ligand
BDBM469729
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
2.00±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469729
Synonyms:
US10807988, Example SC_3365 | cis-8-Dimethylamino-3-[3-fluoro-5-(2-oxo-1,3-dihydro-indol-4-yl)-pyridin-2-yl]-8- phenyl-1,3-diazaspiro[4.5]decan-2-one
Type:
Small organic molecule
Emp. Form.:
C29H30FN5O2
Mol. Mass.:
499.5792
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2)c2ncc(cc2F)-c2cccc3NC(=O)Cc23)CC1)c1ccccc1 |r,wU:6.11,3.2,(17.03,-26.63,;15.49,-26.63,;14.72,-25.3,;14.72,-27.97,;13.95,-29.3,;12.41,-29.3,;11.64,-27.97,;10.73,-26.72,;9.27,-27.2,;9.27,-28.74,;7.93,-29.51,;10.73,-29.21,;8.34,-26.29,;6.85,-26.69,;5.77,-25.6,;6.16,-24.11,;7.65,-23.71,;8.74,-24.8,;10.23,-24.4,;5.07,-23.02,;3.59,-23.42,;2.5,-22.33,;2.9,-20.84,;4.38,-20.45,;5.08,-19.07,;6.6,-19.31,;7.69,-18.22,;6.85,-20.83,;5.47,-21.53,;12.41,-26.63,;13.95,-26.63,;15.49,-29.3,;14.72,-30.63,;15.49,-31.97,;17.03,-31.97,;17.8,-30.63,;17.03,-29.3,)|
Structure:
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