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Target
Nociceptin receptor
Ligand
BDBM469750
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
2.00±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469750
Synonyms:
US10807988, Example SC_3387 | cis-8-Dimethylamino-3-[6-(2-oxo-1,3-dihydro-indol-4-yl)-pyridin-3-yl]-8-phenyl- 1,3-diazaspiro[4.5]decan-2-one
Type:
Small organic molecule
Emp. Form.:
C29H31N5O2
Mol. Mass.:
481.5887
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2)c2ccc(nc2)-c2cccc3NC(=O)Cc23)CC1)c1ccccc1 |r,wU:6.11,3.2,(19.02,12.27,;17.54,12.67,;17.14,14.15,;16.45,11.58,;15.68,10.24,;14.14,10.24,;13.37,11.58,;12.46,12.82,;11,12.35,;11,10.81,;9.66,10.04,;12.46,10.33,;9.66,13.12,;9.66,14.66,;8.33,15.43,;7,14.66,;7,13.12,;8.33,12.35,;5.66,15.43,;5.66,16.97,;4.33,17.74,;2.99,16.97,;2.99,15.43,;1.85,14.4,;2.48,12.99,;1.71,11.66,;4.01,13.15,;4.33,14.66,;14.14,12.91,;15.68,12.91,;17.54,10.49,;17.14,9,;18.23,7.91,;19.71,8.31,;20.11,9.8,;19.02,10.89,)|
Structure:
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