Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM469752
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
2.00±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469752
Synonyms:
US10807988, Example SC_3389 | cis-3-[6-(Azetidin-1-yl)-5-(trifluoromethyl)-pyridin-3-yl]-8-dimethylamino-8- phenyl-1,3-diazaspiro[4.5]decan-2-one
Type:
Small organic molecule
Emp. Form.:
C25H30F3N5O
Mol. Mass.:
473.5338
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2)c2cnc(N3CCC3)c(c2)C(F)(F)F)CC1)c1ccccc1 |r,wU:6.11,3.2,(15.71,-.73,;14.17,-.73,;13.4,.6,;13.4,-2.06,;12.63,-3.4,;11.09,-3.4,;10.32,-2.06,;9.41,-.82,;7.95,-1.29,;7.95,-2.83,;6.62,-3.6,;9.41,-3.31,;6.86,-.2,;7.26,1.28,;6.17,2.37,;4.68,1.97,;3.59,3.06,;3.59,4.6,;2.05,4.6,;2.05,3.06,;4.28,.49,;5.37,-.6,;2.8,.09,;2.4,1.58,;3.2,-1.4,;1.31,-.31,;11.09,-.73,;12.63,-.73,;14.17,-3.4,;13.4,-4.73,;14.17,-6.06,;15.71,-6.06,;16.48,-4.73,;15.71,-3.4,)|
Structure:
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