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Target
Nociceptin receptor
Ligand
BDBM469787
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.30±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469787
Synonyms:
CIS-6-[[2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-acetyl]amino]-N-methyl-pyridine-2-carboxylic acid amide | US10807989, Example SC_1015
Type:
Small organic molecule
Emp. Form.:
C30H40N6O3
Mol. Mass.:
532.677
SMILES:
CNC(=O)c1cccc(NC(=O)CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)n1 |r,wU:15.31,18.21,(.96,-2.32,;2.05,-3.41,;3.54,-3.01,;3.94,-1.52,;4.63,-4.1,;4.23,-5.59,;5.32,-6.68,;6.81,-6.28,;7.2,-4.79,;8.69,-4.39,;9.78,-5.48,;9.38,-6.97,;11.27,-5.08,;12.36,-6.17,;13.82,-5.7,;14.73,-6.94,;15.5,-8.28,;17.04,-8.28,;17.81,-6.94,;17.04,-5.61,;15.5,-5.61,;18.58,-5.61,;17.81,-4.28,;20.12,-5.61,;18.58,-8.28,;17.81,-9.61,;18.58,-10.94,;20.12,-10.94,;20.89,-9.61,;20.12,-8.28,;13.82,-8.19,;14.22,-9.68,;13.13,-10.76,;11.59,-10.76,;11.59,-12.3,;13.13,-12.3,;12.36,-7.71,;11.02,-8.48,;6.12,-3.7,)|
Structure:
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