Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM469807
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.30±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469807
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N-(2-methyl-pyrimidin-5-yl)-acetamide | US10807989, Example SC_1035
Type:
Small organic molecule
Emp. Form.:
C28H38N6O2
Mol. Mass.:
490.6403
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3cnc(C)nc3)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.23,3.2,(16.76,19.16,;17.16,17.68,;18.65,17.28,;16.07,16.59,;15.3,15.25,;13.76,15.25,;12.99,16.59,;12.09,17.83,;10.62,17.36,;9.29,18.13,;7.95,17.36,;7.95,15.82,;6.62,18.13,;5.29,17.36,;3.95,18.13,;2.62,17.36,;2.62,15.82,;1.29,15.05,;3.95,15.05,;5.29,15.82,;10.62,15.82,;9.29,15.05,;12.09,15.34,;12.49,13.85,;11.72,12.52,;10.23,12.12,;10.63,10.63,;12.11,11.03,;13.76,17.92,;15.3,17.92,;17.16,15.5,;16.76,14.01,;17.85,12.92,;19.34,13.32,;19.74,14.81,;18.65,15.9,)|
Structure:
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