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Target
Nociceptin receptor
Ligand
BDBM469824
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.60±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469824
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N-(6-methylsulfonyl-pyridin-3-yl)-acetamide | US10807989, Example SC_1052
Type:
Small organic molecule
Emp. Form.:
C29H39N5O4S
Mol. Mass.:
553.716
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3ccc(nc3)S(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.26,3.2,(-2.33,16.73,;-3.82,17.13,;-4.22,18.62,;-4.91,16.04,;-5.68,14.71,;-7.22,14.71,;-7.99,16.04,;-8.89,17.29,;-10.36,16.81,;-11.45,17.9,;-12.93,17.5,;-13.33,16.01,;-14.02,18.59,;-15.51,18.19,;-16.6,19.28,;-18.09,18.88,;-18.49,17.39,;-17.4,16.3,;-15.91,16.7,;-19.97,16.99,;-19.58,15.51,;-21.46,16.6,;-20.37,18.48,;-10.36,15.27,;-11.69,14.5,;-8.89,14.79,;-8.49,13.31,;-9.58,12.22,;-11.12,12.22,;-11.12,10.68,;-9.58,10.68,;-7.22,17.37,;-5.68,17.37,;-3.82,14.95,;-4.22,13.46,;-3.13,12.37,;-1.64,12.77,;-1.24,14.26,;-2.33,15.35,)|
Structure:
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