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Target
Nociceptin receptor
Ligand
BDBM469835
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.60±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469835
Synonyms:
CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-(3-hydroxy-piperidin-1-yl)-2- oxo-ethyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one | US10807989, Example SC_1063
Type:
Small organic molecule
Emp. Form.:
C28H42N4O3
Mol. Mass.:
482.6581
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)N3CCCC(O)C3)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:3.2,6.22,(13.93,12.49,;15.02,11.4,;16.51,11.8,;14.62,9.92,;14.62,8.38,;13.29,7.61,;11.96,8.38,;10.55,9,;9.52,7.86,;8.03,8.26,;6.94,7.17,;7.34,5.68,;5.46,7.57,;5.06,9.05,;3.57,9.45,;2.48,8.36,;2.88,6.88,;1.79,5.79,;4.37,6.48,;10.29,6.52,;9.89,5.04,;11.8,6.84,;12.89,5.76,;12.49,4.27,;11.15,3.5,;11.92,2.16,;13.26,2.93,;11.96,9.92,;13.29,10.69,;16.11,9.52,;16.51,8.03,;18,7.63,;19.09,8.72,;18.69,10.21,;17.2,10.61,)|
Structure:
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