Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM469848
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
0.800±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469848
Synonyms:
CIS-6-[[2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-acetyl]amino]-pyridine-2-carboxylic acid amide | US10807989, Example SC_1076
Type:
Small organic molecule
Emp. Form.:
C29H38N6O3
Mol. Mass.:
518.6504
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3cccc(n3)C(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.25,3.2,(20.47,-25.11,;18.98,-24.71,;18.58,-23.22,;17.89,-25.8,;17.12,-27.13,;15.58,-27.13,;14.81,-25.8,;13.9,-24.55,;12.44,-25.03,;11.11,-24.26,;9.77,-25.03,;9.77,-26.57,;8.44,-24.26,;7.1,-25.03,;7.1,-26.57,;5.77,-27.34,;4.44,-26.57,;4.44,-25.03,;5.77,-24.26,;3.1,-24.26,;1.77,-25.03,;3.1,-22.72,;12.44,-26.57,;11.11,-27.34,;13.9,-27.05,;14.3,-28.53,;13.21,-29.62,;11.67,-29.62,;11.67,-31.16,;13.21,-31.16,;15.58,-24.47,;17.12,-24.47,;19.22,-26.57,;19.22,-28.11,;20.56,-28.88,;21.89,-28.11,;21.89,-26.57,;20.56,-25.8,)|
Structure:
Search PDB for entries with ligand similarity: