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Target
Nociceptin receptor
Ligand
BDBM469850
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.30±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469850
Synonyms:
CIS-2-[[2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-acetyl]amino]-acetamide | US10807989, Example SC_1078
Type:
Small organic molecule
Emp. Form.:
C25H37N5O3
Mol. Mass.:
455.593
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)NCC(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.19,3.2,(18.12,29.98,;16.58,29.98,;15.81,31.31,;15.81,28.65,;15.04,27.31,;13.5,27.31,;12.73,28.65,;11.83,29.89,;10.36,29.42,;9.03,30.19,;7.69,29.42,;7.3,27.93,;6.36,30.19,;5.03,29.42,;3.69,30.19,;2.36,29.42,;3.69,31.73,;10.36,27.88,;9.03,27.11,;11.83,27.4,;12.23,25.91,;11.14,24.82,;9.6,24.82,;9.6,23.28,;11.14,23.28,;13.5,29.98,;15.04,29.98,;16.58,27.31,;15.81,25.98,;16.58,24.65,;18.12,24.65,;18.89,25.98,;18.12,27.31,)|
Structure:
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