Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM469854
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.000±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469854
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N-thiazol-2-yl-acetamide | US10807989, Example SC_1082
Type:
Small organic molecule
Emp. Form.:
C26H35N5O2S
Mol. Mass.:
481.653
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3nccs3)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.21,3.2,(13.06,5.68,;14.14,4.59,;15.63,4.99,;13.75,3.1,;13.75,1.56,;12.41,.79,;11.08,1.56,;9.79,2.4,;8.59,1.43,;7.1,1.83,;6.01,.74,;6.41,-.74,;4.53,1.14,;3.44,.05,;1.9,.05,;1.42,-1.41,;2.67,-2.32,;3.91,-1.41,;9.14,-0,;8.37,-1.34,;10.68,.08,;11.77,-1.01,;11.37,-2.5,;10.04,-3.27,;10.81,-4.6,;12.14,-3.83,;11.08,3.1,;12.41,3.87,;15.23,2.7,;15.63,1.22,;17.12,.82,;18.21,1.91,;17.81,3.4,;16.32,3.79,)|
Structure:
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