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Target
Nociceptin receptor
Ligand
BDBM469855
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.50±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469855
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N-(5-methyl-isoxazol-3-yl)-acetamide | US10807989, Example SC_1083
Type:
Small organic molecule
Emp. Form.:
C27H37N5O3
Mol. Mass.:
479.6144
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3cc(C)on3)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.22,3.2,(-7.52,-7.57,;-6.43,-8.66,;-4.94,-8.26,;-6.83,-10.15,;-6.83,-11.69,;-8.16,-12.46,;-9.5,-11.69,;-10.79,-10.85,;-11.99,-11.82,;-13.47,-11.42,;-14.56,-12.51,;-14.16,-14,;-16.05,-12.11,;-17.14,-13.2,;-18.68,-13.2,;-19.15,-14.66,;-20.64,-15.06,;-17.91,-15.57,;-16.66,-14.66,;-11.43,-13.26,;-12.2,-14.59,;-9.9,-13.18,;-8.81,-14.26,;-9.21,-15.75,;-10.54,-16.52,;-9.77,-17.86,;-8.44,-17.09,;-9.5,-10.15,;-8.16,-9.38,;-5.34,-10.55,;-4.94,-12.03,;-3.46,-12.43,;-2.37,-11.34,;-2.77,-9.86,;-4.25,-9.46,)|
Structure:
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