Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM469871
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.50±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469871
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N-[(4-methoxy-pyridin-3-yl)-methyl]-acetamide | US10807989, Example SC_1099
Type:
Small organic molecule
Emp. Form.:
C30H41N5O3
Mol. Mass.:
519.6782
SMILES:
COc1ccncc1CNC(=O)CN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O |r,wU:15.32,18.22,(-20.17,7.27,;-19.08,8.36,;-19.47,9.85,;-20.96,10.24,;-21.36,11.73,;-20.27,12.82,;-18.78,12.42,;-18.39,10.93,;-16.9,10.54,;-15.81,11.63,;-14.32,11.23,;-13.92,9.74,;-13.23,12.32,;-11.75,11.92,;-10.55,12.89,;-9.26,12.05,;-7.92,11.28,;-6.59,12.05,;-6.59,13.59,;-7.92,14.36,;-9.26,13.59,;-6.19,15.08,;-7.28,16.16,;-4.7,15.47,;-5.1,13.19,;-4.7,11.7,;-3.22,11.3,;-2.13,12.39,;-2.53,13.88,;-4.01,14.28,;-9.66,10.56,;-8.57,9.47,;-8.97,7.98,;-10.3,7.21,;-9.53,5.88,;-8.2,6.65,;-11.19,10.48,;-11.96,9.15,)|
Structure:
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