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Target
Nociceptin receptor
Ligand
BDBM469876
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.20±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469876
Synonyms:
CIS-6-[[2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-acetyl]amino]-N-methyl-pyridine-3-carboxylic acid amide | US10807989, Example SC_1104
Type:
Small organic molecule
Emp. Form.:
C30H40N6O3
Mol. Mass.:
532.677
SMILES:
CNC(=O)c1ccc(NC(=O)CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)nc1 |r,wU:14.30,17.20,(.66,-11.16,;2.15,-10.76,;3.24,-11.85,;2.84,-13.33,;4.72,-11.45,;5.81,-12.54,;7.3,-12.14,;7.7,-10.65,;9.19,-10.25,;10.28,-11.34,;9.88,-12.83,;11.76,-10.94,;12.85,-12.03,;14.32,-11.56,;15.22,-12.8,;15.99,-14.14,;17.53,-14.14,;18.3,-12.8,;17.53,-11.47,;15.99,-11.47,;19.07,-11.47,;18.3,-10.13,;20.61,-11.47,;19.07,-14.14,;18.3,-15.47,;19.07,-16.8,;20.61,-16.8,;21.38,-15.47,;20.61,-14.14,;14.32,-14.05,;14.71,-15.54,;13.63,-16.62,;12.09,-16.62,;12.09,-18.16,;13.63,-18.16,;12.85,-13.57,;11.52,-14.34,;6.61,-9.56,;5.12,-9.96,)|
Structure:
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