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Target
Nociceptin receptor
Ligand
BDBM469972
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.20±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469972
Synonyms:
CIS-2-[[2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-acetyl]amino]-acetamide | US10807989, Example SC_1206
Type:
Small organic molecule
Emp. Form.:
C25H37N5O3
Mol. Mass.:
455.593
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)NCC(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:3.2,6.19,(-5.72,-21.54,;-4.95,-22.88,;-3.41,-22.88,;-5.72,-24.21,;-6.49,-25.54,;-8.03,-25.54,;-8.8,-24.21,;-9.71,-22.96,;-11.17,-23.44,;-12.5,-22.67,;-13.84,-23.44,;-13.84,-24.98,;-15.17,-22.67,;-16.51,-23.44,;-17.84,-22.67,;-19.17,-23.44,;-17.84,-21.13,;-11.17,-24.98,;-12.5,-25.75,;-9.71,-25.45,;-9.31,-26.94,;-10.4,-28.03,;-11.94,-28.03,;-11.94,-29.57,;-10.4,-29.57,;-8.03,-22.88,;-6.49,-22.88,;-4.95,-25.54,;-5.72,-26.88,;-4.95,-28.21,;-3.41,-28.21,;-2.64,-26.88,;-3.41,-25.54,)|
Structure:
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