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Target
Nociceptin receptor
Ligand
BDBM469980
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.000±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469980
Synonyms:
CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-(1,1-dioxo-[1,4]thiazinan-4-yl)-2- oxo-ethyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one | US10807989, Example SC_1214
Type:
Small organic molecule
Emp. Form.:
C27H40N4O4S
Mol. Mass.:
516.696
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)N3CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.23,3.2,(-7.34,-21.48,;-6.57,-22.81,;-5.03,-22.81,;-7.34,-24.15,;-8.11,-25.48,;-9.65,-25.48,;-10.42,-24.15,;-11.33,-22.9,;-12.79,-23.38,;-13.88,-22.29,;-15.37,-22.69,;-15.77,-24.18,;-16.46,-21.6,;-16.06,-20.11,;-17.15,-19.02,;-18.64,-19.42,;-18.64,-17.88,;-20.12,-19.82,;-19.04,-20.91,;-17.95,-22,;-12.79,-24.92,;-14.13,-25.69,;-11.33,-25.39,;-10.93,-26.88,;-12.02,-27.97,;-13.56,-27.97,;-13.56,-29.51,;-12.02,-29.51,;-9.65,-22.81,;-8.11,-22.81,;-6.57,-25.48,;-7.34,-26.82,;-6.57,-28.15,;-5.03,-28.15,;-4.26,-26.82,;-5.03,-25.48,)|
Structure:
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