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Target
Nociceptin receptor
Ligand
BDBM469996
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.50±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469996
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N-pyrimidin-4-yl-acetamide | US10807989, Example SC_1230
Type:
Small organic molecule
Emp. Form.:
C27H36N6O2
Mol. Mass.:
476.6137
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3ccncn3)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.22,3.2,(13.2,-7.07,;14.29,-8.16,;15.78,-7.76,;13.89,-9.65,;13.89,-11.19,;12.56,-11.96,;11.22,-11.19,;9.93,-10.35,;8.73,-11.32,;7.25,-10.92,;6.16,-12.01,;6.56,-13.5,;4.67,-11.61,;3.58,-12.7,;3.98,-14.19,;2.89,-15.28,;1.4,-14.88,;1,-13.39,;2.09,-12.3,;9.29,-12.76,;8.52,-14.09,;10.82,-12.68,;11.91,-13.77,;11.51,-15.25,;10.18,-16.02,;10.95,-17.36,;12.28,-16.59,;11.22,-9.65,;12.56,-8.88,;15.38,-10.05,;15.78,-11.53,;17.26,-11.93,;18.35,-10.84,;17.95,-9.36,;16.47,-8.96,)|
Structure:
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