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Target
Nociceptin receptor
Ligand
BDBM469998
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.40±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469998
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N-pyridazin-3-yl-acetamide | US10807989, Example SC_1232
Type:
Small organic molecule
Emp. Form.:
C27H36N6O2
Mol. Mass.:
476.6137
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3cccnn3)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.22,3.2,(13.2,-19.94,;14.29,-21.03,;15.78,-20.63,;13.89,-22.52,;13.89,-24.06,;12.56,-24.83,;11.22,-24.06,;9.93,-23.22,;8.73,-24.19,;7.25,-23.79,;6.16,-24.88,;6.56,-26.37,;4.67,-24.48,;3.58,-25.57,;2.09,-25.17,;1,-26.26,;1.4,-27.75,;2.89,-28.15,;3.98,-27.06,;9.29,-25.63,;8.52,-26.96,;10.82,-25.55,;11.91,-26.64,;11.51,-28.12,;10.18,-28.89,;10.95,-30.23,;12.28,-29.46,;11.22,-22.52,;12.56,-21.75,;15.38,-22.92,;15.78,-24.41,;17.26,-24.81,;18.35,-23.72,;17.95,-22.23,;16.47,-21.83,)|
Structure:
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