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Target
Nociceptin receptor
Ligand
BDBM469999
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
0.500±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469999
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N-pyrimidin-5-yl-acetamide | US10807989, Example SC_1233
Type:
Small organic molecule
Emp. Form.:
C27H36N6O2
Mol. Mass.:
476.6137
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3cncnc3)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.22,3.2,(-4.1,21.01,;-5.59,21.41,;-5.99,22.9,;-6.68,20.32,;-7.45,18.99,;-8.99,18.99,;-9.76,20.32,;-10.67,21.57,;-12.13,21.09,;-13.22,22.18,;-14.71,21.78,;-15.11,20.3,;-15.8,22.87,;-17.28,22.47,;-17.68,20.99,;-19.17,20.59,;-20.26,21.68,;-19.86,23.16,;-18.37,23.56,;-12.13,19.55,;-13.46,18.78,;-10.67,19.08,;-9.9,17.74,;-10.67,16.41,;-12.15,16.01,;-11.76,14.52,;-10.27,14.92,;-8.99,21.66,;-7.45,21.66,;-5.59,19.23,;-5.99,17.75,;-4.9,16.66,;-3.41,17.06,;-3.02,18.54,;-4.1,19.63,)|
Structure:
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