Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM470015
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.40±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM470015
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N-pyridin-2-yl-acetamide | US10807989, Example SC_1317
Type:
Small organic molecule
Emp. Form.:
C28H37N5O2
Mol. Mass.:
475.6257
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3ccccn3)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.22,3.2,(14.5,-19.52,;15.58,-20.61,;17.07,-20.21,;15.19,-22.1,;15.19,-23.64,;13.85,-24.41,;12.52,-23.64,;11.23,-22.8,;10.03,-23.77,;8.54,-23.37,;7.45,-24.46,;7.85,-25.94,;5.97,-24.06,;4.88,-25.15,;5.28,-26.64,;4.19,-27.72,;2.7,-27.33,;2.3,-25.84,;3.39,-24.75,;10.58,-25.2,;9.81,-26.54,;12.12,-25.12,;13.21,-26.21,;12.81,-27.7,;11.48,-28.47,;12.25,-29.8,;13.58,-29.03,;12.52,-22.1,;13.85,-21.33,;16.67,-22.5,;17.07,-23.98,;18.56,-24.38,;19.65,-23.29,;19.25,-21.8,;17.76,-21.41,)|
Structure:
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