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Target
Nociceptin receptor
Ligand
BDBM470037
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.000±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM470037
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-8-(3-fluorophenyl)-2-oxo-1,3- diazaspiro[4.5]decan-3-yl]-N-(2-hydroxy-ethyl)-N-methyl-acetamide | US10807989, Example SC_1345
Type:
Small organic molecule
Emp. Form.:
C26H39FN4O3
Mol. Mass.:
474.6113
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)N(C)CCO)C(=O)N2CC2CCC2)CC1)c1cccc(F)c1 |r,wU:6.19,3.2,(-8.72,17.65,;-7.95,16.31,;-6.41,16.31,;-8.72,14.98,;-9.49,13.65,;-11.03,13.65,;-11.8,14.98,;-12.71,16.23,;-14.17,15.75,;-15.26,16.84,;-16.75,16.44,;-17.15,14.95,;-17.84,17.53,;-17.44,19.02,;-19.32,17.13,;-20.41,18.22,;-19.64,19.55,;-14.17,14.21,;-15.5,13.44,;-12.71,13.74,;-12.31,12.25,;-13.4,11.16,;-14.94,11.16,;-14.94,9.62,;-13.4,9.62,;-11.03,16.31,;-9.49,16.31,;-7.95,13.65,;-8.72,12.31,;-7.95,10.98,;-6.41,10.98,;-5.64,12.31,;-4.1,12.31,;-6.41,13.65,)|
Structure:
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