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Target
Nociceptin receptor
Ligand
BDBM470041
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.000±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM470041
Synonyms:
CIS-N-(Carbamoyl-methyl)-2-[1-(cyclobutyl-methyl)-8-dimethylamino-8-(3- fluorophenyl)-2-oxo-1,3-diazaspiro[4.5]decan-3-yl]-N-methyl-acetamide | US10807989, Example SC_1349
Type:
Small organic molecule
Emp. Form.:
C26H38FN5O3
Mol. Mass.:
487.61
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)N(C)CC(N)=O)C(=O)N2CC2CCC2)CC1)c1cccc(F)c1 |r,wU:6.20,3.2,(-6.24,-6.67,;-5.47,-8,;-3.93,-8,;-6.24,-9.33,;-7.01,-10.67,;-8.55,-10.67,;-9.32,-9.33,;-10.23,-8.09,;-11.69,-8.56,;-12.78,-7.47,;-14.27,-7.87,;-14.67,-9.36,;-15.36,-6.78,;-14.96,-5.3,;-16.85,-7.18,;-17.94,-6.09,;-19.48,-6.09,;-17.17,-4.76,;-11.69,-10.1,;-13.03,-10.87,;-10.23,-10.58,;-9.83,-12.07,;-10.92,-13.16,;-12.46,-13.16,;-12.46,-14.7,;-10.92,-14.7,;-8.55,-8,;-7.01,-8,;-5.47,-10.67,;-6.24,-12,;-5.47,-13.33,;-3.93,-13.33,;-3.16,-12,;-1.62,-12,;-3.93,-10.67,)|
Structure:
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