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Target
Nociceptin receptor
Ligand
BDBM470043
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.000±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM470043
Synonyms:
CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-methyl]-3-[2-(4-methylsulfonyl- piperidin-1-yl)-2-oxo-ethyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one | US10807989, Example SC_1351
Type:
Small organic molecule
Emp. Form.:
C29H44N4O5S
Mol. Mass.:
560.748
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)N3CCC(CC3)S(C)(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1 |r,wU:6.25,3.2,(-5.65,-21.92,;-4.88,-23.25,;-3.34,-23.25,;-5.65,-24.59,;-6.42,-25.92,;-7.96,-25.92,;-8.73,-24.59,;-9.63,-23.34,;-11.1,-23.82,;-12.43,-23.05,;-13.76,-23.82,;-13.76,-25.36,;-15.1,-23.05,;-15.1,-21.51,;-16.43,-20.74,;-17.76,-21.51,;-17.76,-23.05,;-16.43,-23.82,;-19.1,-20.74,;-20.43,-21.51,;-19.87,-19.4,;-18.33,-19.4,;-11.1,-25.36,;-12.43,-26.13,;-9.63,-25.83,;-8.86,-27.17,;-9.95,-28.26,;-8.62,-29.03,;-11.49,-28.26,;-11.49,-29.8,;-9.95,-29.8,;-7.96,-23.25,;-6.42,-23.25,;-4.88,-25.92,;-5.65,-27.25,;-4.88,-28.59,;-3.34,-28.59,;-2.57,-27.25,;-3.34,-25.92,)|
Structure:
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