Target

Ligand

Substrate

Meas. Tech.

Kinase Inhibition Assay

Temperature

303.15±n/a K

Citation

 Lu, H; Chang, DJ; Baratte, B; Meijer, L; Schulze-Gahmen, U Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. J Med Chem 48:737-43 (2005) [PubMed]  Article Copy BDB DOI

More Info.:

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Name:

Glycogen synthase kinase-3 beta

Synonyms:

GSK-3, beta | GSK3B_RAT | Glycogen Synthase Kinase-3, beta | Gsk3b

Type:

Enzyme

Mol. Mass.:

46754.43

Organism:

Rattus norvegicus (rat)

Description:

The rat GSK-3 beta cDNA was inserted into the baculovirus vector. The protein was purified from virus-infected sf9 insect cells

Residue:

420

Sequence:

MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDMWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPANATAASDTNAGDRGQTNNAASASASNST

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Blast E-value cutoff:

Name:

BDBM7461

Synonyms:

5,7-dihydroxy-2-phenyl-4H-chromen-4-one | 5,7-dihydroxy-2-phenyl-chromen-4-one | 5,7-dihydroxyflavone | CHEMBL117 | chrysin | cid_5281607

Type:

Small organic molecule

Emp. Form.:

C15H10O4

Mol. Mass.:

254.2375

SMILES:

Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccccc1

Structure:

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Similarity to this molecule at least:

Name:

GSK-3 Peptide Substrate

Synonyms:

GS-1 Peptide | Phospho-GS2 Substrate Peptide

Type:

Peptide

Mol. Mass.:

3045.17

Organism:

n/a

Description:

n/a

Residue:

27

Sequence:

YRRAAVPPSPSLSRHSSPHQSPEDEEE