Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM471739
Substrate
n/a
Meas. Tech.
Pim Enzyme Assay
IC50
<100±n/a nM
Citation
 Xue, C; Li, Y; Feng, H; Zhang, K Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors US Patent  US10828290 Publication Date 11/10/2020 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM471739
Synonyms:
US10828290, Example 22 (Diastereoisomer 2)
Type:
Small organic molecule
Emp. Form.:
C25H24F3N5O2
Mol. Mass.:
483.4856
SMILES:
N[C@H]1CCCN(C1)c1c2CCC(O)c2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:1.0,(-5.48,3.28,;-4.15,2.51,;-2.82,3.28,;-1.48,2.51,;-1.48,.97,;-2.82,.2,;-4.15,.97,;-2.82,-1.34,;-4.15,-2.11,;-5.61,-1.63,;-6.52,-2.88,;-5.61,-4.13,;-6.09,-5.59,;-4.15,-3.65,;-2.82,-4.42,;-1.48,-3.65,;-1.48,-2.11,;-.15,-1.34,;1.18,-2.11,;1.18,-3.65,;2.52,-1.34,;3.85,-2.11,;5.19,-1.34,;5.19,.2,;6.52,.97,;3.85,.97,;2.52,.2,;3.85,2.51,;2.52,3.28,;1.18,2.51,;2.52,4.82,;3.85,5.59,;5.19,4.82,;5.19,3.28,;6.52,2.51,)|
Structure:
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