Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM377183
Substrate
n/a
Meas. Tech.
Pim Enzyme Assay
IC50
<100±n/a nM
Citation
 Xue, C; Li, Y; Feng, H; Zhang, K Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors US Patent  US10828290 Publication Date 11/10/2020 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM377183
Synonyms:
N-{4-[(3S)-3-Aminopiperidin-1-yl]-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide | US10265307, Example 33 | US10517858, Example 33 | US10828290, Example 33 | US11229631, Example 33
Type:
Small organic molecule
Emp. Form.:
C25H25F3N6O
Mol. Mass.:
482.5008
SMILES:
N[C@H]1CCCN(C1)c1c(NC(=O)c2ccc(F)c(n2)-c2c(F)cccc2F)cnc2NCCCc12 |r,wU:1.0,(-5.33,2.69,;-4,1.93,;-2.67,2.69,;-1.33,1.93,;-1.33,.39,;-2.67,-.38,;-4,.39,;-2.67,-1.92,;-1.33,-2.69,;,-1.92,;1.33,-2.69,;1.33,-4.23,;2.67,-1.92,;4,-2.7,;5.33,-1.92,;5.33,-.38,;6.67,.39,;4,.39,;2.67,-.38,;4,1.93,;2.67,2.69,;1.33,1.93,;2.67,4.23,;4,5,;5.33,4.23,;5.33,2.69,;6.67,1.93,;-1.33,-4.23,;-2.67,-5,;-4,-4.23,;-5.33,-5,;-6.67,-4.23,;-6.67,-2.69,;-5.33,-1.92,;-4,-2.69,)|
Structure:
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