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Target
Tyrosine-protein kinase Lck
Ligand
BDBM7463
Substrate
n/a
Meas. Tech.
Kinase Inhibition Assay
IC50
>50000±n/a nM
Citation
 Brana, MF; Cacho, M; Garcia, ML; Mayoral, EP; Lopez, B; de Pascual-Teresa, B; Ramos, A; Acero, N; Llinares, F; Munoz-Mingarro, D; Lozach, O; Meijer, L Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases. J Med Chem 48:6843-54 (2005) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM7463
Synonyms:
4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-3-amine | Pyrazolopyridazine 1a | Pyrazolopyridazine deriv. 1a | pyrazolopyridazine deriv. 1
Type:
Small organic molecule
Emp. Form.:
C17H13N5
Mol. Mass.:
287.3186
SMILES:
Nc1n[nH]c2nnc(-c3ccccc3)c(-c3ccccc3)c12
Structure:
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