Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM471850
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
2.70±n/a nM
Citation
Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Konetzki, I 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives US Patent US10829480 Publication Date 11/10/2020
More Info.:
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
Inhibitor
Name:
BDBM471850
Synonyms:
CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[(4-methylsulfonyl-phenyl)-methyl]- 8-phenyl-1,3-diazaspiro[4.5]decan-2-one | US10829480, Example SC_2001
Type:
Small organic molecule
Emp. Form.:
C29H39N3O3S
Mol. Mass.:
509.703
SMILES:
CN(C)[C@]1(CC[C@]2(CN(Cc3ccc(cc3)S(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.23,3.2,(-6.07,31.9,;-5.67,30.41,;-4.18,30.01,;-6.76,29.32,;-7.53,27.99,;-9.07,27.99,;-9.84,29.32,;-10.74,30.57,;-12.21,30.09,;-13.54,30.86,;-14.88,30.09,;-16.21,30.86,;-17.54,30.09,;-17.54,28.55,;-16.21,27.78,;-14.88,28.55,;-18.88,27.78,;-19.65,29.12,;-20.21,27.01,;-18.11,26.45,;-12.21,28.55,;-13.54,27.78,;-10.74,28.08,;-10.35,26.59,;-11.44,25.5,;-12.98,25.5,;-12.98,23.96,;-11.44,23.96,;-9.07,30.66,;-7.53,30.66,;-5.67,28.23,;-6.07,26.75,;-4.98,25.66,;-3.49,26.05,;-3.09,27.54,;-4.18,28.63,)|