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Target
Mu-type opioid receptor
Ligand
BDBM471984
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
1.10±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Konetzki, I 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10829480 Publication Date 11/10/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM471984
Synonyms:
CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-8-phenyl-3-(pyrazin-2-yl-methyl)-1,3- diazaspiro[4.5]decan-2-one | US10829480, Example SC_2007
Type:
Small organic molecule
Emp. Form.:
C26H35N5O
Mol. Mass.:
433.589
SMILES:
CN(C)[C@]1(CC[C@]2(CN(Cc3cnccn3)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.19,3.2,(-8.95,-1.96,;-8.56,-3.45,;-7.07,-3.85,;-9.65,-4.54,;-10.42,-5.87,;-11.96,-5.87,;-12.73,-4.54,;-13.63,-3.29,;-15.09,-3.77,;-16.43,-3,;-17.76,-3.77,;-17.76,-5.31,;-19.1,-6.08,;-20.43,-5.31,;-20.43,-3.77,;-19.1,-3,;-15.09,-5.31,;-16.43,-6.08,;-13.63,-5.79,;-13.23,-7.27,;-14.32,-8.36,;-15.86,-8.36,;-15.86,-9.9,;-14.32,-9.9,;-11.96,-3.21,;-10.42,-3.21,;-8.56,-5.63,;-8.95,-7.12,;-7.87,-8.21,;-6.38,-7.81,;-5.98,-6.32,;-7.07,-5.23,)|
Structure:
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