Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM472017
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
180±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Konetzki, I 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10829480 Publication Date 11/10/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM472017
Synonyms:
CIS-1-(Cyclopentyl-methyl)-8-dimethylamino-3-[(4-methoxyphenyl)-methyl]-8- phenyl-1,3-diazaspiro[4.5]decan-2-one | US10829480, Example SC_2023
Type:
Small organic molecule
Emp. Form.:
C30H41N3O2
Mol. Mass.:
475.6654
SMILES:
COc1ccc(CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCCC3)C2=O)cc1 |r,wU:9.25,12.15,(-20.06,17.9,;-18.72,17.13,;-17.39,17.9,;-17.39,19.44,;-16.06,20.21,;-14.72,19.44,;-13.39,20.21,;-12.05,19.44,;-10.59,19.92,;-9.68,18.67,;-8.91,17.34,;-7.37,17.34,;-6.6,18.67,;-7.37,20,;-8.91,20,;-5.83,20,;-6.6,21.34,;-4.29,20,;-5.83,17.34,;-6.6,16,;-5.83,14.67,;-4.29,14.67,;-3.52,16,;-4.29,17.34,;-10.59,17.42,;-10.19,15.94,;-11.28,14.85,;-12.8,15.09,;-13.5,13.72,;-12.41,12.63,;-11.04,13.33,;-12.05,17.9,;-13.39,17.13,;-14.72,17.9,;-16.06,17.13,)|
Structure:
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