Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM472047
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
1320±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Konetzki, I 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10829480 Publication Date 11/10/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM472047
Synonyms:
CIS-3-[8-Dimethylamino-3-[(4-methoxyphenyl)-methyl]-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-1-yl]-2,2-dimethyl-propionitrile | US10829480, Example SC_2100
Type:
Small organic molecule
Emp. Form.:
C29H38N4O2
Mol. Mass.:
474.6376
SMILES:
COc1ccc(CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC(C)(C)C#N)C2=O)cc1 |r,wU:9.25,12.15,(2.87,-9.83,;2.87,-8.29,;4.2,-7.52,;4.2,-5.98,;5.54,-5.21,;6.87,-5.98,;8.2,-5.21,;9.54,-5.98,;11,-5.5,;11.91,-6.75,;12.68,-8.08,;14.22,-8.08,;14.99,-6.75,;14.22,-5.41,;12.68,-5.41,;15.76,-5.41,;14.99,-4.08,;17.3,-5.41,;15.76,-8.08,;14.99,-9.41,;15.76,-10.75,;17.3,-10.75,;18.07,-9.41,;17.3,-8.08,;11,-7.99,;11.4,-9.48,;10.31,-10.57,;9.22,-9.48,;8.98,-11.34,;10.71,-12.06,;11.11,-13.54,;9.54,-7.52,;8.2,-8.29,;6.87,-7.52,;5.54,-8.29,)|
Structure:
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