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Target
Nociceptin receptor
Ligand
BDBM472069
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
134±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Konetzki, I 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10829480 Publication Date 11/10/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM472069
Synonyms:
CIS-3-[[8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-methyl]-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-methyl]-benzamide | US10829480, Example SC_2110
Type:
Small organic molecule
Emp. Form.:
C29H38N4O3
Mol. Mass.:
490.637
SMILES:
CN(C)[C@]1(CC[C@]2(CN(Cc3cccc(c3)C(N)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1 |r,wU:6.22,3.2,(16.68,-8.53,;17.45,-9.87,;18.99,-9.87,;16.68,-11.2,;15.91,-12.54,;14.37,-12.54,;13.6,-11.2,;12.7,-9.96,;11.23,-10.43,;9.9,-9.66,;8.57,-10.43,;8.57,-11.97,;7.23,-12.74,;5.9,-11.97,;5.9,-10.43,;7.23,-9.66,;4.57,-9.66,;3.23,-10.43,;4.57,-8.12,;11.23,-11.97,;9.9,-12.74,;12.7,-12.45,;13.1,-13.94,;12.01,-15.02,;13.34,-15.79,;10.47,-15.02,;10.47,-16.56,;12.01,-16.56,;14.37,-9.87,;15.91,-9.87,;17.45,-12.54,;16.68,-13.87,;17.45,-15.2,;18.99,-15.2,;19.76,-13.87,;18.99,-12.54,)|
Structure:
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