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Target
Mu-type opioid receptor
Ligand
BDBM472083
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
3.80±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Konetzki, I 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10829480 Publication Date 11/10/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM472083
Synonyms:
CIS-4-[[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-methyl-benzonitrile | US10829480, Example SC_2085
Type:
Small organic molecule
Emp. Form.:
C29H36N4O
Mol. Mass.:
456.6223
SMILES:
CN(C)[C@]1(CC[C@]2(CN(Cc3ccc(cc3)C#N)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.21,3.2,(14.48,29.87,;15.25,28.54,;16.79,28.54,;14.48,27.21,;13.71,25.87,;12.17,25.87,;11.4,27.21,;10.5,28.45,;9.03,27.98,;7.7,28.75,;6.37,27.98,;5.03,28.75,;3.7,27.98,;3.7,26.44,;5.03,25.67,;6.37,26.44,;2.37,25.67,;1.03,24.9,;9.03,26.44,;7.7,25.67,;10.5,25.96,;10.9,24.47,;9.81,23.39,;8.27,23.39,;8.27,21.85,;9.81,21.85,;12.17,28.54,;13.71,28.54,;15.25,25.87,;14.48,24.54,;15.25,23.21,;16.79,23.21,;17.56,24.54,;16.79,25.87,)|
Structure:
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