Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM472089
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
110±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Konetzki, I 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10829480 Publication Date 11/10/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM472089
Synonyms:
CIS-3-[[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-methyl]-benzamide | US10829480, Example SC_2088
Type:
Small organic molecule
Emp. Form.:
C29H38N4O2
Mol. Mass.:
474.6376
SMILES:
CN(C)[C@]1(CC[C@]2(CN(Cc3cccc(c3)C(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.22,3.2,(-6.82,-10.71,;-6.05,-12.04,;-4.51,-12.04,;-6.82,-13.38,;-7.59,-14.71,;-9.13,-14.71,;-9.9,-13.38,;-10.8,-12.13,;-12.27,-12.61,;-13.6,-11.84,;-14.93,-12.61,;-14.93,-14.15,;-16.27,-14.92,;-17.6,-14.15,;-17.6,-12.61,;-16.27,-11.84,;-18.94,-11.84,;-20.27,-12.61,;-18.94,-10.3,;-12.27,-14.15,;-13.6,-14.92,;-10.8,-14.62,;-10.4,-16.11,;-11.49,-17.2,;-13.03,-17.2,;-13.03,-18.74,;-11.49,-18.74,;-9.13,-12.04,;-7.59,-12.04,;-6.05,-14.71,;-6.82,-16.04,;-6.05,-17.38,;-4.51,-17.38,;-3.74,-16.04,;-4.51,-14.71,)|
Structure:
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