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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM472818
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
33.6±n/a nM
Citation
 Ahmad, S; Li, L; Negash, LA; Hynes, J Thienopyridines and benzothiophenes useful as IRAK4 inhibitors US Patent  US10829496 Publication Date 11/10/2020 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM472818
Synonyms:
US10829496, Example 22
Type:
Small organic molecule
Emp. Form.:
C17H20FN3O4S
Mol. Mass.:
381.422
SMILES:
CC[C@H]1[C@@H](COc2c(C)sc3cc(C(N)=O)c(OC)nc23)NC(=O)[C@H]1F |r|
Structure:
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