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Target
Bromodomain-containing protein 4 [49-170]
Ligand
BDBM472702
Substrate
n/a
Meas. Tech.
In vitro Bromodomain Inhibition Assay
IC50
2580±n/a nM
Citation
 Jacquemot, G; Claridge, S; Bayrakdarian, M; Johnstone, S; Albert, JS; Griffin, A N-substituted bicyclic lactams, their preparation and their use as pharmaceuticals US Patent  US10836742 Publication Date 11/17/2020 
Target
Name:
Bromodomain-containing protein 4 [49-170]
Synonyms:
BRD4 | BRD4-BD1 | BRD4-BD1 (aa 49-170) | BRD4_HUMAN | Bromodomain containing 4 (aa 49-170) | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(49-170) | Bromodomain-containing protein 4 (BRD4)(BD1) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14593.14
Organism:
Homo sapiens (Human)
Description:
aa 49-170 (BRD4-BD1)
Residue:
122
Sequence:
ETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETE
  
Inhibitor
Name:
BDBM472702
Synonyms:
US10836742, Compound 6
Type:
Small organic molecule
Emp. Form.:
C24H24N2O3
Mol. Mass.:
388.459
SMILES:
COc1cc(cc2CCC(=O)N(Cc3ccccc3)c12)-c1cc(C)c(=O)n(C)c1
Structure:
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