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Target
Bromodomain-containing protein 4 [49-170]
Ligand
BDBM472843
Substrate
n/a
Meas. Tech.
In vitro Bromodomain Inhibition Assay
IC50
860±n/a nM
Citation
 Jacquemot, G; Claridge, S; Bayrakdarian, M; Johnstone, S; Albert, JS; Griffin, A N-substituted bicyclic lactams, their preparation and their use as pharmaceuticals US Patent  US10836742 Publication Date 11/17/2020 
Target
Name:
Bromodomain-containing protein 4 [49-170]
Synonyms:
BRD4 | BRD4-BD1 | BRD4-BD1 (aa 49-170) | BRD4_HUMAN | Bromodomain containing 4 (aa 49-170) | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(49-170) | Bromodomain-containing protein 4 (BRD4)(BD1) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14593.14
Organism:
Homo sapiens (Human)
Description:
aa 49-170 (BRD4-BD1)
Residue:
122
Sequence:
ETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETE
  
Inhibitor
Name:
BDBM472843
Synonyms:
US10836742, Compound 11
Type:
Small organic molecule
Emp. Form.:
C21H22F2N2O2
Mol. Mass.:
372.4084
SMILES:
Cc1cc(cn(C)c1=O)-c1ccc2CCC(=O)N(CC3CC(F)(F)C3)c2c1
Structure:
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