Reaction Details Report a problem with these data
Target
Histone deacetylase 2
Ligand
BDBM473794
Substrate
n/a
Meas. Tech.
HDAC Enzyme Assays
IC50
82.0±n/a nM
Citation
 Golonzhka, O; Jarpe, MB HDAC inhibitors for the treatment of diabetic peripheral neuropathy US Patent  US10858323 Publication Date 12/8/2020 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM473794
Synonyms:
N-hydroxy-2-((2-methoxy-5-(trifluoromethyl)benzyl)amino)pyrimidine-5-carboxamide | US10858323, Compound 3
Type:
Small organic molecule
Emp. Form.:
C14H13F3N4O3
Mol. Mass.:
342.2732
SMILES:
COc1ccc(cc1CNc1ncc(cn1)C(=O)NO)C(F)(F)F
Structure:
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