Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM474234
Substrate
n/a
Meas. Tech.
Binding Affinities to Different Adenosine Receptors
IC50
1.70±n/a nM
Citation
 Zeng, Q; Qi, C; Tsui, H; Yang, Z; Zhang, X Triazolo-pyrimidine compounds and uses thereof US Patent  US10858365 Publication Date 12/8/2020 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM474234
Synonyms:
5-(5-amino-2-((3-fluoropyridin-2-yl)methyl)-7- (4-methoxyphenyl)-[1,2,4]triazolo[1,5-c]pyrimidin- 8-yl)-1-methylpyridin-2(1H)-one | US10858365, Compound 61 | US11629147, Cmpd. 61
Type:
Small organic molecule
Emp. Form.:
C24H20FN7O2
Mol. Mass.:
457.4597
SMILES:
COc1ccc(cc1)-c1nc(N)n2nc(Cc3ncccc3F)nc2c1-c1ccc(=O)n(C)c1
Structure:
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