Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM474288
Substrate
n/a
Meas. Tech.
FLIPR and cAMP Inhibition Assay
IC50
14.0±n/a nM
Citation
 Zeng, Q; Qi, C; Tsui, H; Yang, Z; Zhang, X Triazolo-pyrimidine compounds and uses thereof US Patent  US10858365 Publication Date 12/8/2020 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM474288
Synonyms:
2-((3-(difluoromethoxy)pyridin-2-yl)methyI)-8- (imidazo[1,2-a]pyridin-6-yl)-7-(oxazol-2-yl)-[ 1,2, 4]triazolo[1,5-c]pyrimidin-5-amine | US10858365, Compound 74
Type:
Small organic molecule
Emp. Form.:
C21H14F2N10O2
Mol. Mass.:
476.3985
SMILES:
Nc1nc(-c2ncco2)c(-c2ccc3nncn3c2)c2nc(Cc3ncccc3OC(F)F)nn12
Structure:
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