Reaction Details Report a problem with these data
Target
Neuraminidase
Ligand
BDBM474368
Substrate
n/a
EC50
560±n/a nM
Citation
 Jain, R; Koester, DC; Manning, JR; Sutton, JC; Taft, BR; Wan, L; Zhao, Q Tricyclic compounds useful to treat orthomyxovirus infections US Patent  US10858366 Publication Date 12/8/2020 
Target
Name:
Neuraminidase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
51409.73
Organism:
n/a
Description:
Q1P9S2
Residue:
466
Sequence:
MNPNQKIIAIGSVSLTIATICFLMQIAILATTMTLHFKQNECSNPSNNQVVPCEPIIIEKNIVHLNNTTIEKKICPKVAEYKNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREPYVSCGLGKCYQFALGQGTTLKNKHSNGTTHDRIPHRTLLMNELGVPFHLGTKQVCIAWSSSSCHDGKAWLHVCVTGDDKNATASIIYDGMLVDSIGSWSKNILRTQESECVCINGTCTVVMTDGSASGKADTRILFIREGKIVHISPLSGSAQHVEECSCYPRYPEVRCVCRDNWKGSNRPVLYINMADYSIESSYVCSGLVGDTPRNDDSSSSSNCKDPNNERGAPGVKGWAFDNGNDIWMGRTIKEDSRSGYETFRVVGGWTTANSKSQINRQVIVDSENWSGYSGIFSVEGKNCINRCFYVELIRGRPQETRVWWTSNSIIVFCGTSGTYGTGSWPDGANINFMPI
 
Inhibitor
Name:
BDBM474368
Synonyms:
(S)-6-(bis(4-fluorophenyl)methyl)-3-bromo- 11-hydroxy-5,6-dihydro-10H- imidazo[2',1':3,4]pyrazino[1,2-b]pyridazin-10- one | US10858366, Example 47
Type:
Small organic molecule
Emp. Form.:
C22H15BrF2N4O2
Mol. Mass.:
485.281
SMILES:
Oc1c2-c3ncc(Br)n3C[C@H](C(c3ccc(F)cc3)c3ccc(F)cc3)n2ncc1=O |r|
Structure:
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