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Target
MAP kinase-interacting serine/threonine-protein kinase 2
Ligand
BDBM475222
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
60.0±n/a nM
Citation
 Schiltz, GE; Izquierdo-Ferrer, J; Vagadia, P; Clutter, MR; Mishra, RK; Platanias, LC Substituted aromatic n-heterocyclic compounds as inhibitors of mitogen-activated protein kinase interacting kinase 1 (MNK1) and 2 (MNK2) US Patent  US10851082 Publication Date 12/1/2020 
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 2
Synonyms:
GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2
Type:
Protein
Mol. Mass.:
51870.79
Organism:
Homo sapiens (Human)
Description:
Q9HBH9
Residue:
465
Sequence:
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAGQGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
  
Inhibitor
Name:
BDBM475222
Synonyms:
US10851082, NUCC-0176153 | US10851082, NUCC-0176167
Type:
Small organic molecule
Emp. Form.:
C18H21N5O
Mol. Mass.:
323.3922
SMILES:
COC1CCC(CC1)Nc1nccc(n1)-n1cnc2ccccc12 |(-3.32,-6.8,;-4.4,-5.71,;-4.01,-4.22,;-5.09,-3.13,;-4.7,-1.65,;-3.21,-1.25,;-2.12,-2.34,;-2.52,-3.82,;-2.81,.24,;-1.32,.64,;-.23,-.45,;1.25,-.05,;1.65,1.44,;.56,2.53,;-.92,2.13,;.96,4.01,;.06,5.26,;.96,6.5,;2.43,6.03,;3.76,6.8,;5.09,6.03,;5.09,4.49,;3.76,3.72,;2.43,4.49,)|
Structure:
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